Managing AML: Staying on Track in a Rapidly Changing Treatment Landscape
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Chapter 1 of 3
Release Date: September 9, 2020
Expiration Date: September 9, 2021
Expected time to complete this activity as designed: 60 minutes
There are no fees for participating in or receiving credit for this online activity.
There have been many advances to improve patient outcomes in AML, however, this can be challenging for clinicians to stay abreast of the fast pace of developments in treatment. In this activity, three experts cover novel targeted therapies for AML in both the frontline and relapsed/refractory setting, the role of mutational profiling in individualizing treatment, and emerging approaches with the potential to shape the current treatment landscape. This program will conclude with three unique case presentations as the experts share their insights to treatment selection.
This activity is designed for multidisciplinary healthcare providers in the community setting, including hematologists, oncologists, nurses, pharmacists and other allied healthcare professionals who provide care to patients with acute myeloid leukemia.
Upon completion of this educational activity, participants should be able to:
- Summarize best practice strategies in molecular and mutational analysis in AML which assist in developing a patient-centered treatment approach
- Improve knowledge of new and emerging evidence in maintenance therapy as a new standard of care in AML
- Outline guidelines and clinical trial evidence to identify appropriate treatment approaches for patients with AML
- Describe strategies for identifying and managing treatment including dosing, and management of toxicities associated with novel and emerging therapies in AML
Chapter 1 - Overview of the AML Treatment Landscape – Naval Daver, MD - Chair
Chapter 2 - Progress and Challenges in Frontline Treatment – Courtney D. DiNardo, MD, MSCE
Chapter 3 - Molecular and Immunotherapies: Moving the Bar in Relapsed/Refractory AML – Eunice S. Wang, MD
Chapter 4 - Case Library: The Art and Science of Treatment Selection – Naval Daver, MD – Chair; Courtney D. DiNardo, MD, MSCE; Eunice S. Wang, MD
Instructions for Participation and Credit
This activity is eligible for credit through December 31, 2020. After this date, this activity will expire and no further credit will be awarded.
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Naval Daver, MD – Chair
Department of Leukemia
The University of Texas MD Anderson Cancer Center
Dr. Naval Daver received his medical degree from Grant Medical College and Sir JJ Group of Hospitals, Mumbai, India, followed by a residency and fellowship in hematology-oncology from Baylor College of Medicine in Houston, Texas. He is an Associate Professor in the Department of Leukemia at The University of Texas MD Anderson Cancer Center.
A clinical investigator with a focus on molecular and immune therapies in acute myeloid leukemia (AML) and myelofibrosis, Dr. Daver is the co/principal investigator for more than 25 ongoing clinical trials in these diseases. These trials focus on developing a personalized therapy approach by targeting specific mutations or immune pathways expressed by patients with AML, evaluating novel combinations of targeted, immune and cytotoxic agents, and identifying and overcoming mechanism of resistance. He is especially interested in developing immune checkpoint- and vaccine-based approaches in AML, myelodysplastic syndromes (MDS), and myelofibrosis, and is conducting a number of these trials. Dr. Daver has published more than 100 peer-reviewed manuscripts. He has also authored numerous abstracts at national and international conferences.
Courtney D. DiNardo, MD, MSCE
Associate Professor of Medicine
Department of Leukemia
Division of Cancer Medicine
The University of Texas MD Anderson Cancer Center
Dr. Courtney DiNardo received her medical degree from the University of Michigan, Ann Arbor. She completed her internal medicine internship and residency, followed by a hematology/oncology fellowship at the University of Pennsylvania. Dr. DiNardo is currently Associate Professor of Medicine in the Department of Leukemia, Division of Cancer Medicine, and Institutional Review Board Vice Chair at The University of Texas MD Anderson Cancer Center in Houston, Texas.
Dr. DiNardo’s clinical research focuses on prognostication and personalized therapeutics in myeloid malignancies. She is primary investigator of multiple novel IDH1/IDH2-targeted therapeutic agents currently in clinical trials and is also involved in the clinical development of venetoclax in combination with hypomethylating agent therapy for the treatment of newly diagnosed elderly AML. Her clinical and research focus on hereditary cancer predisposition syndromes led to development of the MD Anderson Hereditary Hematologic Malignancy Clinic, which provides clinical and research-based evaluation of underlying cancer predispositions and hereditary cancer syndromes in leukemia patients.
Eunice S. Wang, MD
Chief, Clinical Leukemia Service
Professor, Department of Medicine
Roswell Park Comprehensive Cancer Center
Buffalo, New York
Dr. Eunice Wang earned her medical degree from the Keck (University of Southern California) School of Medicine. She completed her internship and residency in internal medicine at Yale-New Haven Hospital, followed by clinical and research fellowships in hematology-oncology at Memorial Sloan Kettering Cancer Center in New York. She is Chief of the Leukemia Service and Professor of Oncology in the Department of Medicine at Roswell Park Comprehensive Cancer Center, Buffalo, New York. She is also an Associate Professor in the Department of Medicine, School of Medicine of Biomedical Sciences at the State University of New York at Buffalo (SUNY-UB).
Dr. Wang is a member of several professional organizations including the American Society of Hematology and the American Society of Clinical Oncology. She serves on the National Comprehensive Cancer Network (NCCN) Clinical Practice treatment guidelines panels for acute myeloid and acute lymphocytic leukemia. She is a prior recipient of a NIH Cancer Clinical Investigator Team Leadership Award (CCITLA) and a Mentored Research Scholar award from the American Cancer Society. Dr. Wang has authored/co-authored more than 90 peer-reviewed articles in the field of hematological malignancies. She maintains an active clinical practice with a portfolio of early phase clinical trials in acute leukemias and myeloid malignancies. She also leads a translational laboratory focused on preclinical studies of novel agents targeting the marrow microenvironment and immune responses.
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This activity is supported by educational grant from Actinium Pharmaceuticals, Bristol-Myers Squibb, and Jazz Pharmaceuticals.
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Dr. Naval Daver has received honoraria related to formal advisory activities and as a consultant from AbbVie Inc., Agios, Astellas Pharma US, Inc., Bristol-Myers Squibb Company, Celgene Corporation – A Bristol-Myers Squibb Company, Daiichi Sankyo, Inc., ImmunoGen, Inc., Incyte Corporation, Jazz Pharmaceuticals plc, Karyopharm Therapeutics, Novartis AG, Otsuka Pharmaceutical Co., Ltd., Pfizer Inc., and Sunesis. He has received grant support related to research activities from AbbVie, Bristol-Myers Squibb, Daiichi Sankyo, Genentech, Inc., GlycoMimetics, Inc., ImmunoGen, Incyte, Karyopharm, Nohla Therapeutics, Novartis, Pfizer, SERVIER, and Sunesis.
Dr. Courtney DiNardo has received honoraria as a consultant from AbbVie Inc., Agios, Celgene Corporation – A Bristol-Myers Squibb Company, Daiichi Sankyo, Inc., Immune-Onc Therapeutics, Inc., Novartis AG, and Takeda Oncology. She has received grant support related to research activities from AbbVie, Agios, Celgene Corporation – A Bristol-Myers Squibb Company, Calithera BioSciences, Inc., Daiichi Sankyo, and Immune-Onc. She has also disclosed a financial relationship with Notable.
Dr. Eunice Wang has received honoraria related to formal advisory activities from AbbVie Inc., Astellas Pharma US, Inc., Bristol-Myers Squibb Company, Genentech, Inc., Jazz Pharmaceuticals plc, Kite Pharma, MacroGenics, Inc., Pfizer Inc., and PTC Therapeutics, as well as speakers’ bureau activities from DAVA Oncology, Pfizer, and Stemline Therapeutics, Inc.
Planning Committee Disclosures
The individuals listed below from MediCom Worldwide, Inc. reported the following for this activity: Joan Meyer, RN, MHA, Executive Director, Isabelle Vacher, Vice President of Educational Strategy, Wilma Guerra, Program Director, and Andrea Mathis, Project Manager, have no relevant financial relationships.
Peer Reviewer Disclosure
In accordance with MediCom Worldwide, Inc. policy, all content is reviewed by external independent peer reviewers for balance, objectivity and commercial bias. The peer reviewers have no relevant financial relationships to disclose.
- Chapter 1: Overview of AML; Progress and Challenges in Frontline Treatment – Run Time: 14:08
- Chapter 2: Molecular and Immunotherapies: Moving the Bar in Relapsed/Refractory AML – Run Time: 12:46
- Chapter 3: The Art and Science of Treatment Selection: Case Study Gallery – Run Time: 35:19
- Assessment and Evaluation